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Meth Damage to Brains

Dopamine Pathways Dopamine Pathways In the brain, dopamine plays an important role in the regulation of reward and movement. As part of the reward pathway, dopamine is manufactured in nerve cell bodies located within the ventral tegmental area (VTA) and is released in the nucleus accumbens and the prefrontal cortex. Its motor functions are linked to a separate pathway, with cell bodies in the substantia nigra that manufacture and release dopamine into the striatum.

Short-term effects may include:
  • Increased attention and decreased fatigue
  • Increased activity and wakefulness
  • Decreased appetite
  • Euphoria and rush
  • Increased respiration
  • Rapid/irregular heartbeat
  • Hyperthermia
Long-term effects may include:
  • Addiction
  • Psychosis, including:
    • paranoia
    • hallucinations
    • repetitive motor activity
  • Changes in brain structure and function
  • Memory Loss
  • Aggressive or violent behavior
  • Mood disturbances
  • Severe dental problems
  • Weight loss


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